Klebsiella pneumoniae carbapenemase (KPC)-producing bacteria are a group of emerging highly drug-resistant Gram-negative bacilli causing infections associated with significant morbidity and mortality. Carbapenem antibiotics are generally not effective against KPC-producing organisms. Although K. pneumoniae remains the most prevalent bacterial species carrying KPCs, the enzyme has been identified in several other gram-negative bacilli. Infections caused by bacteria-producing carbapenemases are becoming an increasingly significant problem worldwide because they are often not detected by routine susceptibility screening and possess an exceptional potential for dissemination. Infections caused by these organisms present clinicians with serious treatment challenges, due to limited antibiotic options. Peptones and growth factors provide nitrogen, vitamins, minerals and amino acids essential for growth. Chromogenic mixture allows the identification of Gram-negative bacteria with a reduced susceptibility to the carbapenem agents. The supplement inhibits the growth of all the KPC non-producing bacteria. Characteristics of KPC colonies: - Escherichia coli: colonias pink. - Enterobacter aerogenes: dark blue. - Klebsiella pneumoniae: dark blue.
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